Facile access to unnatural dipeptide-alcohols based on cis-2,5-disubstituted pyrrolidines.
نویسندگان
چکیده
Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, 1H- and 13C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.
منابع مشابه
One-pot tandem cyclization of enantiopure asymmetric cis-2,5-disubstituted pyrrolidines: Facile access to chiral 10-heteroazatriquinanes
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ورودعنوان ژورنال:
- Molecules
دوره 20 2 شماره
صفحات -
تاریخ انتشار 2015